Bringing Glucose Monitoring to New Levels through Integrated Sensor Design
公司规模
Large Corporate
国家
- Worldwide
产品
- COMSOL Multiphysics®
- Roche Glucometers
技术栈
- Multiphysics Simulation
- Michaelis Menten Enzyme Kinetics
- Butler-Volmer Electrode Kinetics
实施规模
- Enterprise-wide Deployment
影响指标
- Productivity Improvements
- Customer Satisfaction
- Innovation Output
技术
- 分析与建模 - 预测分析
- 分析与建模 - 实时分析
- 应用基础设施与中间件 - 数据可视化
适用行业
- 医疗保健和医院
- 生命科学
适用功能
- 产品研发
- 质量保证
用例
- 预测性维护
- 临床图像分析
- 远程病人监护
服务
- 软件设计与工程服务
- 系统集成
关于客户
Roche Diabetes Care, a division of Roche Diagnostics, is a global leader in diabetes diagnostic products and services. The company is dedicated to improving the lives of people with diabetes through innovative solutions and technologies. Roche Diabetes Care offers a wide range of products, including glucose meters, test strips, and insulin delivery systems, designed to help individuals manage their diabetes effectively. With a strong focus on research and development, Roche Diabetes Care continuously strives to enhance the accuracy and reliability of its products, ensuring that users can make informed decisions about their health. The company operates worldwide, providing support and resources to healthcare professionals and patients alike.
挑战
Close metabolic control through glucose monitoring is essential for persons with diabetes to maintain good health and avoid medical complications. However, the chemical reactions on the sensing strips used in glucose monitors are sensitive to environmental conditions and chemical interferences. Sensors are shipped worldwide, stored under uncertain conditions, and used by individuals with varying levels of knowledge and experience. Robust design is crucial for enabling sensors to survive these environments, deliver accurate results, and detect conditions that would cause errors. Multiphysics simulation is now used alongside experiments and calculations, enabling scientists to understand the chemical, electrical, and biological phenomena interacting in these systems so they can optimize their design and measurement methods.
解决方案
Engineers at Roche Diabetes Care are pursuing a better understanding of the electrochemistry in their existing devices and designing new sensing methods to provide more accurate monitoring. Their glucometers measure the electric current that results when a voltage is applied to an electrode system, with the current being proportional to glucose levels in an electrolyte solution. Using COMSOL Multiphysics® software simulations, the Roche team studied a new test strip design and isolated the chemical reactions from the electrical, mechanical, and temperature conditions to analyze the voltage response. They built a one-dimensional model to understand and predict the responses, combining Michaelis Menten enzyme kinetics and mixed Butler-Volmer electrode kinetics. Additionally, they applied an AC signal to obtain impedance information used to compensate for temperature and hematocrit effects. This mathematical algorithm provided the sensor with the information needed to make accurate glucose predictions. The team also built a second model of the cell in 3D to solve the electrical problem, investigating different electrode configurations and materials to predict the sensitivity of the impedance measurements to hematocrit and other mechanical properties of the sensor.
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